What is Rett Syndrome?

Rett syndrome (RTT) is a rare neurological disorder caused by genetic mutations in the MECP2 gene, primarily affecting girls. It impacts speech, movement, eating, and breathing. Symptoms appear as early as 6 months when children miss developmental milestones. While not degenerative, individuals with Rett require lifelong care and can live into adulthood.

What Causes Rett Syndrome?

Rett syndrome results from spontaneous mutations in the MECP2 gene on the X chromosome. These mutations occur randomly at conception and are not inherited or caused by parental actions.

How Can You Help?

Support research and families by donating to the International Rett Syndrome Foundation (IRSF). IRSF funds research, provides family support, and drives advocacy to treat and cure Rett syndrome and create a world without it.